GSK J1

CAS No. 1373422-53-7

GSK J1 ( GSKJ1; GSKJ 1; GSKJ-1 )

Catalog No. M17982 CAS No. 1373422-53-7

GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 36 In Stock
10MG 57 In Stock
25MG 88 In Stock
50MG 168 In Stock
100MG 280 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    GSK J1
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.
  • Description
    GSKJ1 is a selective and potent histone demethylase inhibitor (GSK-J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK-J4: 1 μM < IC50 < 10 μM; e.g. 9 μM in primary human macrophages). The pyridine regio-isomer GSK-J2 displays significantly less on-target activity (IC50 > 100 μM for human JmjD3) and thus can be used as control for target effects in vitro, and as ester derivative (GSK-J5) in cells. Recent data has shown that GSK-J1 also shows some activity (IC50 950 nM for Jarid1b, IC50 1.76 uM for Jarid1c) against H3K4me3/2/1 demethylases.
  • Synonyms
    GSKJ1; GSKJ 1; GSKJ-1
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    JMJD3 (KDM6B);UTX (KDM6A)
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    1373422-53-7
  • Formula Weight
    389.45
  • Molecular Formula
    C22H23N5O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 33 mg/mL; 84.73 mM
  • SMILES
    OC(=O)CCNC1=CC(=NC(=N1)C1=CC=CC=N1)N1CCC2=C(CC1)C=CC=C2
  • Chemical Name
    3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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